Engineered Metalloenzymes for Stereocontrolled Atom Transfer Radical Addition

Over the past three decades, the advent of directed evolution has enabled enhancements to catalytic activity and stereoselectivity through customized enzymes; demonstrating the potential of biocatalysis to revolutionize the practice of asymmetric synthesis. Until recently, however, the catalytic repertoire of enzymes has been mostly limited to reactions found in nature, posing constraints on the types […]